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Anti-inflammatory tripeptide (alpha-MSH fragment)

KPV

Research use only

Written by pep4U Editorial Team · Last reviewed July 8, 2026

A tiny peptide from alpha-MSH that keeps the parent hormone's anti-inflammatory action without causing pigmentation.

Class / typeAnti-inflammatory tripeptide (alpha-MSH fragment)
CategoryHealing, Recovery & Immune
Status (Jul 2026)Research use only

How it works

Binds melanocortin receptors (MC1R/MC3R) and enters cells via PepT1 to inhibit NF-kB, reducing TNF-alpha, IL-6 and other cytokines.

Known / used for

Gut inflammation / IBD models, gut-barrier support, skin inflammation, general anti-inflammatory use.

Positives

Targeted anti-inflammatory action in preclinical colitis; small, stable, orally absorbable; no pigmentation effect.

Negatives & risks

No completed human trials - evidence entirely preclinical; human safety/dosing not established; gray-market purity risk.

Frequently asked questions

What is KPV?
A tiny peptide from alpha-MSH that keeps the parent hormone's anti-inflammatory action without causing pigmentation. Binds melanocortin receptors (MC1R/MC3R) and enters cells via PepT1 to inhibit NF-kB, reducing TNF-alpha, IL-6 and other cytokines.
What is KPV used or researched for?
Gut inflammation / IBD models, gut-barrier support, skin inflammation, general anti-inflammatory use.
Is KPV FDA-approved or legal?
NOT FDA-approved. Under FDA PCAC review Jul 23, 2026 (FDA proposing NOT to list on 503A). Verify.
What are the main risks or downsides of KPV?
No completed human trials - evidence entirely preclinical; human safety/dosing not established; gray-market purity risk.

Legal / regulatory status

NOT FDA-approved. Under FDA PCAC review Jul 23, 2026 (FDA proposing NOT to list on 503A). Verify.

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