Synthetic hexapeptide growth hormone-releasing peptide (GHRP) / ghrelin mimetic
Hexarelin is a potent synthetic peptide that stimulates the body to release its own growth hormone.
| Class / type | Synthetic hexapeptide growth hormone-releasing peptide (GHRP) / ghrelin mimetic |
|---|---|
| Category | Growth Hormone & Muscle |
| Status (Jul 2026) | Research use only |
It binds and activates the growth hormone secretagogue receptor (GHS-R), mimicking ghrelin to trigger pulsatile GH release from the pituitary. It also appears to act on cardiac tissue independent of GH.
Originally investigated for diagnosing and treating growth hormone deficiency; studied in research for GH stimulation, potential cardioprotection, and muscle/recovery effects. Not an approved therapy.
Strong, rapid GH release; researched appetite stimulation and possible cardiac and tissue-protective effects.
Receptor desensitization with continued use (blunting GH response), increased cortisol and prolactin, water retention, increased appetite and weight gain, and lack of human safety validation.
Users report noticeable GH-related effects, faster perceived recovery, and increased appetite; sentiment reported anecdotally, not a medical endorsement.
NOT FDA-approved. It is sold for research use only, has no approved human or veterinary indication, and is banned by WADA at all times under class S2.