Angiotensin IV-derived synthetic nootropic peptide
Dihexa
Research use only
Written by pep4U Editorial Team · Last reviewed July 8, 2026
A small orally-stable peptide derived from angiotensin IV that is being researched for its powerful ability to build new brain synapses.
| Class / type | Angiotensin IV-derived synthetic nootropic peptide |
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| Category | Cognitive & Nootropic |
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| Status (Jul 2026) | Research use only |
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How it works
It potentiates hepatocyte growth factor (HGF) signaling through the c-Met receptor, enhancing downstream pathways associated in animal models with increased dendritic spine density and synaptogenesis.
Known / used for
Preclinical research into memory, learning, cognitive decline, and neurodegenerative conditions such as Alzheimer's disease.
Positives
Reported in rodent studies to be extremely potent at promoting synapse formation and improving memory; orally active and metabolically stable.
Negatives & risks
No human clinical trials; long-term safety unknown; because it stimulates growth-factor pathways there are theoretical cancer-promotion concerns; sold only as an unregulated research chemical of variable purity.
What people like most (reported community sentiment - not endorsement)
Biohacker communities report subjective cognitive enhancement, but reports are anecdotal and safety data is absent.
Frequently asked questions
What is Dihexa?
A small orally-stable peptide derived from angiotensin IV that is being researched for its powerful ability to build new brain synapses. It potentiates hepatocyte growth factor (HGF) signaling through the c-Met receptor, enhancing downstream pathways associated in animal models with increased dendritic spine density and synaptogenesis.
What is Dihexa used or researched for?
Preclinical research into memory, learning, cognitive decline, and neurodegenerative conditions such as Alzheimer's disease.
Is Dihexa FDA-approved or legal?
NOT FDA-approved for any indication; it is an unapproved research chemical sold for laboratory use only and is not authorized for human consumption.
What are the main risks or downsides of Dihexa?
No human clinical trials; long-term safety unknown; because it stimulates growth-factor pathways there are theoretical cancer-promotion concerns; sold only as an unregulated research chemical of variable purity.
Legal / regulatory status
NOT FDA-approved for any indication; it is an unapproved research chemical sold for laboratory use only and is not authorized for human consumption.
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