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Long-acting GHRH analog

CJC-1295 with DAC

Research use only

Written by pep4U Editorial Team · Last reviewed July 8, 2026

A GHRH(1-29) analog modified with a Drug Affinity Complex (DAC) that binds albumin so it lasts ~6-8 days in the body.

Class / typeLong-acting GHRH analog
CategoryGrowth Hormone & Muscle
Status (Jul 2026)Research use only

Key points

  • Long-acting GHRH analog that raises your own growth hormone for days per dose.
  • The DAC (drug affinity complex) binds albumin, extending action to ~6-8 days.
  • Convenient dosing, but produces sustained rather than natural pulsatile GH.
  • Not FDA-approved; research-use-only and WADA-banned.

Overview

CJC-1295 with DAC is a modified fragment of growth-hormone-releasing hormone (GHRH) engineered to last far longer in the body than natural GHRH. The 'DAC' is a chemical group that latches onto albumin in the blood, stretching its activity from minutes to roughly a week.

It is popular in GH-optimization and anti-aging circles for its once- or twice-weekly convenience, but it is not an approved medicine and human data are limited.

How it works

It binds GHRH receptors on the pituitary to stimulate growth-hormone synthesis and release. Because the albumin-binding DAC keeps it circulating for days, it raises GH and IGF-1 in a sustained, relatively flat pattern rather than the sharp natural pulses the body normally produces.

What the research shows

A 2006 Phase 1 study (Teichman et al.) found single doses raised mean GH 2-10 fold and IGF-1 1.5-3 fold for 9-11 days, and it was reasonably well tolerated short-term. There are no long-term human efficacy or safety trials for body composition or anti-aging use, so those benefits rest on that pharmacology plus anecdote.

Benefits

Infrequent dosing and a steady background elevation of GH/IGF-1; users commonly report better sleep, recovery and skin.

Often paired with a GHRP like ipamorelin, which is thought to amplify the GH release.

Risks & side effects

No long-term human safety data. Sustained, non-pulsatile GH/IGF-1 elevation is a theoretical concern for fluid retention, joint pain, carpal-tunnel-type symptoms and insulin resistance.

Anyone with cancer risk should be cautious with anything that chronically raises IGF-1. It is WADA-banned, and gray-market purity is a real concern.

Practical considerations

Sold research-use-only; there is no FDA-sanctioned human dose. The 'with DAC' version is distinct from 'without DAC' (Mod GRF 1-29), which clears in ~30 minutes and better mimics natural pulses.

Frequently asked questions

What does the DAC do?
It binds albumin in the blood so the peptide lasts about 6-8 days instead of minutes, allowing infrequent dosing.
Is CJC-1295 FDA-approved?
No. It is research-use-only and is not an approved medicine; it is also banned in sport (WADA).
With DAC vs without DAC - what's the difference?
With DAC lasts days and gives a sustained GH rise; without DAC (Mod GRF 1-29) lasts ~30 minutes and produces a natural-style pulse, so it's dosed more often.
What benefits do users report?
Better sleep, recovery, skin and body composition - but these are anecdotal; controlled human trials are lacking.
What are the risks?
Fluid retention, joint aches, possible insulin resistance from sustained GH/IGF-1, unknown long-term safety, and purity concerns with gray-market product.

Legal / regulatory status

NOT FDA-approved. Added to Category 2 (2023), removed (2024); pending PCAC review. Research-use-only; WADA-banned.

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