Porcine brain-derived neuropeptide mixture (neurotrophic)
An injectable mixture of small peptides and amino acids derived from pig brain tissue, used abroad to support recovery after stroke, brain injury, and dementia.
| Class / type | Porcine brain-derived neuropeptide mixture (neurotrophic) |
|---|---|
| Category | Cognitive & Nootropic |
| Status (Jul 2026) | Research use only |
It mimics the action of endogenous neurotrophic factors, promoting neuronal survival, synaptic plasticity, and neurogenesis while reducing oxidative stress and excitotoxicity.
Ischemic stroke recovery, traumatic brain injury, vascular dementia, and Alzheimer's disease in countries where it is approved.
Some trials and meta-analyses report improved cognition and functional recovery after stroke and in dementia; long clinical track record abroad; generally well tolerated.
Evidence quality is rated low by Cochrane reviews; key stroke trials (e.g., CASTA) failed; possible injection-site reactions, dizziness, agitation; porcine origin raises allergy and contamination concerns; not standardized in the US.
Users abroad often report subjective improvements in mental clarity and recovery, though sentiment is mixed and reproducibility is questioned.
NOT FDA-approved in the United States for any indication; however, it is approved and marketed in 50+ countries (including Austria, Russia, and China) for stroke, TBI, and dementia.